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The CMRCT program addresses both MR and CT development and clinical applications in an effort to determine the optimal imaging approaches for cardiac patients.
CARDIAC MR
- Measurement of regional myocardial oxygen consumption (MVO2) using cardiac BOLD imaging
- Measurement of Myocardial perfusion with endogenous contrast mechanisms, including BOLD and Arterial Spin Labeling (ASL).
- Characterization of myocardial fiber behavior using strain-diffusion imaging, in normal and diseased hearts
- High resolution 3.0T MR coronary angiograms with free breathing navigators and slice tracking
- Determine efficacy of Gd based contrast agents for 3.0T angiography
- In vivo detection and characterization of plaques with motion corrected "dark blood" imaging sequences
- MR plaque imaging validation in patients receiving OCT and IVUS during catheterization
- Develop 3.0T vessel wall imaging of the carotid bifurcation and aorta for measurement of plaque volumetric burden and composition
- Develop vessel wall strain imaging
- Implement magnetization transfer contrast for characterization of plaque fibrous matrix
- Computational Fluid Dynamics analysis on the combination of high spatial resolution carotid bifurcation structural images and hemodynamics obtained from phase contrast
- MR and PET comparison for detection of inflammation and related markers
- Detailed assessment of mitral valve/subvalvular morphology prior to elective surgical repair (currently not possible at 1.5T). Correlation with current invasive gold standard (TEE).
- Determine arterial wall thickening in patients with primary pulmonary. hypertension versus IVUS
DEVELOPMENT OF INTERVENTIONAL CARDIAC MR
- Development of MR cardiovascular interventions
- Novel intravascular MR coil design
- MR vulnerable plaque detection: imaging and multinuclear spectroscopy
- Development of MR-VT ablation
- MR monitoring of left ventricular function and wall thickening following gene therapy
- Effect of Na-Ca exchanger over-expression on the maintenance of atrial fibrillation
- ARVD assessment with MR imaging; correlation of MR features with subsequent clinical outcomes
- Detailed anatomical mapping of pulmonary veins prior to ablation of atrial fibrillation: correlation of anatomical and electro-physiologic variables
- Role of MR in acute chest pain
- Myocardial viability study
- Scar imaging with delayed enhancement MR to guide RF ablation of ventricular tachycardia
- Determine the utility of MR in the diagnosis and treatment of myocarditis
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